Ontology highlight
ABSTRACT:
SUBMITTER: Hou C
PROVIDER: S-EPMC5039229 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Hou Caixia C Chan Nelson L S NL Gu Liya L Li Guo-Min GM
Nature structural & molecular biology 20090713 8
Expansion of CAG/CTG trinucleotide repeats is associated with certain familial neurological disorders, including Huntington's disease. Increasing evidence suggests that formation of a stable DNA hairpin within CAG/CTG repeats during DNA metabolism contributes to their expansion. However, the molecular mechanism(s) by which cells remove CAG/CTG hairpins remain unknown. Here we demonstrate that human cell extracts can catalyze error-free repair of CAG/CTG hairpins in a nick-directed manner. The re ...[more]