Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
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ABSTRACT:
SUBMITTER: Schoch KM
PROVIDER: S-EPMC5040069 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
Schoch Kathleen M KM DeVos Sarah L SL Miller Rebecca L RL Chun Seung J SJ Norrbom Michaela M Wozniak David F DF Dawson Hana N HN Bennett C Frank CF Rigo Frank F Miller Timothy M TM
Neuron 20160519 5
Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. However, direct assessments of 4R toxicity have not yet been accomplished in vivo. Increasing 4R-tau expression without change to total tau in human tau-expressing mice induced more severe seizures and nesting behavior abnormality, increased tau phosphorylation, and produced a shift toward oligomeric tau. Exon 10 sk ...[more]
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