Dataset Information

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment.

ABSTRACT:

Background & aim

We performed lipid analyses at the early period of therapy in patients with chronic hepatitis C who underwent interferon (IFN)-free direct-acting antiviral (DAA) treatment, and we attempted to identify the factors that contributed to a rapid increase in the patients' serum low-density lipoprotein cholesterol (LDL-C) concentration.

Methods

We retrospectively analyzed the cases of 100 consecutive patients with HCV infection treated at the National Hospital Organization Nagasaki Medical Center: 24 patients underwent daclatasvir (DCV) and asunaprevir (ASV) combination therapy (DCV/ASV) for 24 weeks, and the other 76 patients underwent ledipasvir and sofosbuvir combination therapy (LDV/SOF) for 12 weeks. ?LDL-C was defined as the changed in LDL-C level at 28 days from the start of therapy. To determine whether ?LDL-C was associated with several kinds of factors including viral kinetics, we performed a stepwise multiple linear regression analysis.

Results

The LDL-C levels in patients treated with LDV/SOF were markedly and significantly elevated (87.45 to 122.5 mg/dl; p<10-10) compared to those in the DCV/ASV-treated patients (80.15 to 87.8 mg/dl; p = 0.0056). The median levels of ?LDL-C in the LDV/SOF and DCV/ASV groups were 33.2 and 13.1, respectively. LDV/SOF combination therapy as an IFN-free regimen (p<0.001) and ?HCV core antigen (0-1 day drop) (p<0.044) were identified as independent factors that were closely related to the ?LDL-C.

Conclusions

A rapid increase in the serum LDL-C concentration during the IFN-free treatment of hepatitis C was associated with the type of HCV therapy and a decline of HCV core protein.

SUBMITTER: Hashimoto S

PROVIDER: S-EPMC5040437 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment.

Hashimoto Satoru S Yatsuhashi Hiroshi H Abiru Seigo S Yamasaki Kazumi K Komori Atsumasa A Nagaoka Shinya S Saeki Akira A Uchida Shinjiro S Bekki Shigemune S Kugiyama Yuki Y Nagata Kazuyoshi K Nakamura Minoru M Migita Kiyoshi K Nakao Kazuhiko K

PloS one 20160928 9

<h4>Background & aim</h4>We performed lipid analyses at the early period of therapy in patients with chronic hepatitis C who underwent interferon (IFN)-free direct-acting antiviral (DAA) treatment, and we attempted to identify the factors that contributed to a rapid increase in the patients' serum low-density lipoprotein cholesterol (LDL-C) concentration.<h4>Methods</h4>We retrospectively analyzed the cases of 100 consecutive patients with HCV infection treated at the National Hospital Organizat ...[more]

PMID: 27680885

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Dataset Information

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment.

Background & aim

Methods

Results

Conclusions

Publications

Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment.

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