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Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease.


ABSTRACT: BACKGROUND:Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. AIMS:To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). METHODS:The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases. We utilized data from neuropsychological tests, volumetric magnetic resonance imaging, single-photon emission tomography, cerebrospinal fluid biomarkers and the APOE genotype. The DSI classification results were calculated with a combination of leave-one-out cross-validation and bootstrapping. A DSF visualization of a FTD patient is presented as an example. RESULTS:The DSI distinguishes controls from FTD (area under the receiver-operator curve, AUC = 0.99) and AD (AUC = 1.00) very well and achieves a good differential diagnosis between AD and FTD (AUC = 0.89). In subsamples of autopsy-confirmed cases (AUC = 0.97) and clinically diagnosed cases (AUC = 0.94), differential diagnosis of AD and FTD performs very well. CONCLUSIONS:DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases. Here, DSI separates controls from dementia and differentiates between AD and FTD.

SUBMITTER: Munoz-Ruiz MA 

PROVIDER: S-EPMC5040932 | biostudies-literature | 2016 May-Aug

REPOSITORIES: biostudies-literature

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Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease.

Muñoz-Ruiz Miguel Ángel MÁ   Hall Anette A   Mattila Jussi J   Koikkalainen Juha J   Herukka Sanna-Kaisa SK   Husso Minna M   Hänninen Tuomo T   Vanninen Ritva R   Liu Yawu Y   Hallikainen Merja M   Lötjönen Jyrki J   Remes Anne M AM   Alafuzoff Irina I   Soininen Hilkka H   Hartikainen Päivi P  

Dementia and geriatric cognitive disorders extra 20160501 2


<h4>Background</h4>Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes.<h4>Aims</h4>To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD).<h4>Methods</h4>The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive p  ...[more]

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