Metabolic profile and safety of piperlongumine.
Ontology highlight
ABSTRACT:
SUBMITTER: de Lima Moreira F
PROVIDER: S-EPMC5041077 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Metabolic profile and safety of piperlongumine.
de Lima Moreira Fernanda F Habenschus Maísa D MD Barth Thiago T Marques Lucas M M LM Pilon Alan Cesar AC da Silva Bolzani Vanderlan V Vessecchi Ricardo R Lopes Norberto P NP de Oliveira Anderson R M AR
Scientific reports 20160929
Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predic ...[more]
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