Ontology highlight
ABSTRACT:
SUBMITTER: Do Carmo S
PROVIDER: S-EPMC5041108 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Do Carmo Sonia S Hanzel Cecilia E CE Jacobs Marie L ML Machnes Ziv Z Iulita M Florencia MF Yang Jingyun J Yu Lei L Ducatenzeiler Adriana A Danik Marc M Breuillaud Lionel S LS Bennett David A DA Szyf Moshe M Cuello A Claudio AC
Scientific reports 20160929
General DNA hypomethylation is associated with Alzheimer's disease (AD), but it is unclear when DNA hypomethylation starts or plays a role in AD pathology or whether DNA re-methylation would rescue early amyloid-related cognitive impairments. In an APP transgenic mouse model of AD-like amyloid pathology we found that early intraneuronal amyloid beta build-up is sufficient to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA demethylation in AD-vulnerable bra ...[more]