Dataset Information

Dietary intake of flavonoid subclasses and risk of colorectal cancer: evidence from population studies.

ABSTRACT:

Objective

To systematically evaluate the relationship between flavonoids intake and colorectal cancer risk by conducting a meta-analysis.

Results

Our meta-analysis included 18 studies involving 16,917 colorectal cancer cases in 559,486 participants in relations to flavonoids intake during six to twenty-six years of follow-up. Our results indicated that specific flavonoid subclasses, such as procyanidins (OR = 0.75; 95% CI, 0.66-0.86) and isoflavones (OR = 0.87; 95% CI, 0.78-0.98), showed protective effects against colorectal cancer risk. There was no enough evidence indicating that increased consumption of total flavonoids were significantly associated with reduced risk of colorectal cancer (OR = 0.94, 95% CI, 0.81-1.09). There was no publication bias across studies.

Methods

We performed a systematic search of PubMed, Web of Science and the Cochrane Library databases for relevant articles before December 2015. A random-effects model was used to estimate summary odds ratios and 95% confidence intervals (CIs) for associations between flavonoids and colorectal cancer risk. We assessed heterogeneity among studies by the Cochran Q and I2 statistics.

Conclusions

Our meta-analysis provides comprehensive evidence and partly supported the hypothesis that higher habitual intake of foods rich in procyanidins and isoflavones may potentially decrease colorectal cancer incidence. More prospective studies are warranted to verify this protective association.

SUBMITTER: He X

PROVIDER: S-EPMC5042003 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

Dietary intake of flavonoid subclasses and risk of colorectal cancer: evidence from population studies.

He Xingkang X Sun Lei-Min LM

Oncotarget 20160501 18

<h4>Objective</h4>To systematically evaluate the relationship between flavonoids intake and colorectal cancer risk by conducting a meta-analysis.<h4>Results</h4>Our meta-analysis included 18 studies involving 16,917 colorectal cancer cases in 559,486 participants in relations to flavonoids intake during six to twenty-six years of follow-up. Our results indicated that specific flavonoid subclasses, such as procyanidins (OR = 0.75; 95% CI, 0.66-0.86) and isoflavones (OR = 0.87; 95% CI, 0.78-0.98), ...[more]

PMID: 27058896

Similar Datasets

Project description:BackgroundThis study aimed to explore the potential interaction between dietary intake and genetics on incident colorectal cancer (CRC) and whether adherence to healthy dietary habits could attenuate CRC risk in individuals at high genetic risk.MethodsWe analyzed prospective cohort data of 374,004 participants who were free of any cancers at enrollment in UK Biobank. Dietary scores were created based on three dietary recommendations of the World Cancer Research Fund (WCRF) and the overall effects of 11 foods on CRC risks using the inverse-variance (IV) method. Genetic risk was assessed using a polygenic risk score (PRS) capturing overall CRC risk. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs (confidence intervals) of associations. Interactions between dietary factors and the PRS were examined using a likelihood ratio test to compare models with and without the interaction term.ResultsDuring a median follow-up of 12.4 years, 4,686 CRC cases were newly diagnosed. Both low adherence to the WCRF recommendations (HR = 1.12, 95% CI = 1.05-1.19) and high IV-weighted dietary scores (HR = 1.27, 95% CI = 1.18-1.37) were associated with CRC risks. The PRS of 98 genetic variants was associated with an increased CRC risk (HRT3vsT1 = 2.12, 95% CI = 1.97-2.29). Participants with both unfavorable dietary habits and a high PRS had a more than twofold increased risk of developing CRC; however, the interaction was not significant. Adherence to an overall healthy diet might attenuate CRC risks in those with high genetic risks (HR = 1.21, 95% CI = 1.08-1.35 for high vs. low IV-weighted dietary scores), while adherence to WCRF dietary recommendations showed marginal effects only (HR = 1.09, 95% CI = 1.00-1.19 for low vs. high WCRF dietary scores).ConclusionDietary habits and the PRS were independently associated with CRC risks. Adherence to healthy dietary habits may exert beneficial effects on CRC risk reduction in individuals at high genetic risk.

Dataset Information

Dietary intake of flavonoid subclasses and risk of colorectal cancer: evidence from population studies.

Objective

Results

Methods

Conclusions

Publications

Dietary intake of flavonoid subclasses and risk of colorectal cancer: evidence from population studies.

Similar Datasets

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