Ontology highlight
ABSTRACT:
SUBMITTER: Bao Y
PROVIDER: S-EPMC5042014 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Oncotarget 20160501 18
PRSS8 is a membrane-anchored serine protease prostasin and has been shown an association with carcinogenesis. Herein we found that PRSS8 expression was significantly reduced in colorectal adenomas and adenocarcinomas. The decreased PRSS8 was well correlated with clinical stages, poor differentiation and shorter survival time of colorectal cancer. Furthermore, increase of PRSS8 led to the inhibition of colorectal cancer cell proliferation, knockdown of PRSS8 accelerated cell proliferation in vitr ...[more]