Ontology highlight
ABSTRACT:
SUBMITTER: Alperovich A
PROVIDER: S-EPMC5042201 | biostudies-literature | 2016 Jan-Feb
REPOSITORIES: biostudies-literature
Alperovich Anna A Younes Anas A
Cancer journal (Sudbury, Mass.) 20160101 1
The expression of CD30 receptors is one of the defining characteristics of the malignant Reed-Sternberg cells of Hodgkin lymphoma (HL). CD30 is rarely expressed by normal cells and is rapidly internalized, making it an ideal therapeutic target for monoclonal antibodies and for antibody-drug conjugates. Brentuximab vedotin is the first antibody-drug conjugate to be approved by regulatory agencies for the treatment of patients with relapsed HL, with a single-agent response rate of 75%. In this rev ...[more]