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Targeting CD30 Using Brentuximab Vedotin in the Treatment of Hodgkin Lymphoma.

ABSTRACT: The expression of CD30 receptors is one of the defining characteristics of the malignant Reed-Sternberg cells of Hodgkin lymphoma (HL). CD30 is rarely expressed by normal cells and is rapidly internalized, making it an ideal therapeutic target for monoclonal antibodies and for antibody-drug conjugates. Brentuximab vedotin is the first antibody-drug conjugate to be approved by regulatory agencies for the treatment of patients with relapsed HL, with a single-agent response rate of 75%. In this review article, we discuss the current and ongoing development of brentuximab vedotin in patients with relapsed and newly diagnosed HL.

SUBMITTER: Alperovich A

PROVIDER: S-EPMC5042201 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature

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Targeting CD30 Using Brentuximab Vedotin in the Treatment of Hodgkin Lymphoma.

Alperovich Anna A Younes Anas A

Cancer journal (Sudbury, Mass.) 20160101 1

The expression of CD30 receptors is one of the defining characteristics of the malignant Reed-Sternberg cells of Hodgkin lymphoma (HL). CD30 is rarely expressed by normal cells and is rapidly internalized, making it an ideal therapeutic target for monoclonal antibodies and for antibody-drug conjugates. Brentuximab vedotin is the first antibody-drug conjugate to be approved by regulatory agencies for the treatment of patients with relapsed HL, with a single-agent response rate of 75%. In this rev ...[more]

PMID: 26841013

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