Brentuximab Vedotin in CD30+ Lymphomas.
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ABSTRACT:
SUBMITTER: Perini GF
PROVIDER: S-EPMC3873074 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Publications
Brentuximab Vedotin in CD30+ Lymphomas.
Perini Guilherme Fleury GF Pro Barbara B
Biologics in therapy 20130301
Monoclonal antibodies (mAb) have become an effective treatment strategy for hematologic malignancies. CD30 is a rational target for therapy due to its limited expression on normal tissues and the strong and uniform expression on malignant cells in classical Hodgkin's lymphoma (cHL) and anaplastic large-cell lymphoma (ALCL). Brentuximab vedotin, an anti-CD30 antibody-drug conjugate, utilizes the targeting properties of mAb to deliver a cytotoxic agent inside the malignant cell. Brentuximab vedoti ...[more]
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