Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5042529 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Liu Xiling X Han Dingding D Somel Mehmet M Jiang Xi X Hu Haiyang H Guijarro Patricia P Zhang Ning N Mitchell Amanda A Halene Tobias T Ely John J JJ Sherwood Chet C CC Hof Patrick R PR Qiu Zilong Z Pääbo Svante S Akbarian Schahram S Khaitovich Philipp P
PLoS biology 20160929 9
Cognitive defects in autism spectrum disorder (ASD) include socialization and communication: key behavioral capacities that separate humans from other species. Here, we analyze gene expression in the prefrontal cortex of 63 autism patients and control individuals, as well as 62 chimpanzees and macaques, from natal to adult age. We show that among all aberrant expression changes seen in ASD brains, a single aberrant expression pattern overrepresented in genes involved synaptic-related pathways is ...[more]