Ontology highlight
ABSTRACT:
SUBMITTER: Sckolnick M
PROVIDER: S-EPMC5042576 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sckolnick Maria M Krementsova Elena B EB Warshaw David M DM Trybus Kathleen M KM
Molecular biology of the cell 20160817 19
Tropomyosin (Tpm) isoforms decorate actin with distinct spatial and temporal localization patterns in cells and thus may function to sort actomyosin processes by modifying the actin track affinity for specific myosin isoforms. We examined the effect of three Tpm isoforms on the ability of myosin Va (myoVa) to engage with actin in vitro in the absence or presence of the cargo adapter melanophilin (Mlph), which links myoVa to Rab27a-melanosomes for in vivo transport. We show that both the myosin m ...[more]