Ontology highlight
ABSTRACT:
SUBMITTER: Behrmann E
PROVIDER: S-EPMC4163373 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Cell 20120701 2
Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of contractile events in muscle and nonmuscle cells. However, little is known about molecular interactions within the complex and the trajectory of tropomyosin movement between its "open" and "closed" positions on the actin filament. Here, we report the 8 Å resolution structure of the rigor (nucleotide-free) actin-tropomyosin-myosin complex determined by cryo-electron microscopy. The pseudoatomic model of ...[more]