Ontology highlight
ABSTRACT:
SUBMITTER: Ehret GB
PROVIDER: S-EPMC5042863 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ehret Georg B GB Ferreira Teresa T Chasman Daniel I DI Jackson Anne U AU Schmidt Ellen M EM Johnson Toby T Thorleifsson Gudmar G Luan Jian'an J Donnelly Lousie A LA Kanoni Stavroula S Petersen Ann-Kristin AK Pihur Vasyl V Strawbridge Rona J RJ Shungin Dmitry D Hughes Maria F MF Meirelles Osorio O Kaakinen Marika M Bouatia-Naji Nabila N Kristiansson Kati K Shah Sonia S Kleber Marcus E ME Guo Xiuqing X Lyytikäinen Leo-Pekka LP Fava Cristiano C Eriksson Niclas N Nolte Ilja M IM Magnusson Patrik K PK Salfati Elias L EL Rallidis Loukianos S LS Theusch Elizabeth E Smith Andrew J P AJP Folkersen Lasse L Witkowska Kate K Pers Tune H TH Joehanes Roby R Kim Stuart K SK Lataniotis Lazaros L Jansen Rick R Johnson Andrew D AD Warren Helen H Kim Young Jin YJ Zhao Wei W Wu Ying Y Tayo Bamidele O BO Bochud Murielle M Absher Devin D Adair Linda S LS Amin Najaf N Arking Dan E DE Axelsson Tomas T Baldassarre Damiano D Balkau Beverley B Bandinelli Stefania S Barnes Michael R MR Barroso Inês I Bevan Stephen S Bis Joshua C JC Bjornsdottir Gyda G Boehnke Michael M Boerwinkle Eric E Bonnycastle Lori L LL Boomsma Dorret I DI Bornstein Stefan R SR Brown Morris J MJ Burnier Michel M Cabrera Claudia P CP Chambers John C JC Chang I-Shou IS Cheng Ching-Yu CY Chines Peter S PS Chung Ren-Hua RH Collins Francis S FS Connell John M JM Döring Angela A Dallongeville Jean J Danesh John J de Faire Ulf U Delgado Graciela G Dominiczak Anna F AF Doney Alex S F ASF Drenos Fotios F Edkins Sarah S Eicher John D JD Elosua Roberto R Enroth Stefan S Erdmann Jeanette J Eriksson Per P Esko Tonu T Evangelou Evangelos E Evans Alun A Fall Tove T Farrall Martin M Felix Janine F JF Ferrières Jean J Ferrucci Luigi L Fornage Myriam M Forrester Terrence T Franceschini Nora N Duran Oscar H Franco OHF Franco-Cereceda Anders A Fraser Ross M RM Ganesh Santhi K SK Gao He H Gertow Karl K Gianfagna Francesco F Gigante Bruna B Giulianini Franco F Goel Anuj A Goodall Alison H AH Goodarzi Mark O MO Gorski Mathias M Gräßler Jürgen J Groves Christopher C Gudnason Vilmundur V Gyllensten Ulf U Hallmans Göran G Hartikainen Anna-Liisa AL Hassinen Maija M Havulinna Aki S AS Hayward Caroline C Hercberg Serge S Herzig Karl-Heinz KH Hicks Andrew A AA Hingorani Aroon D AD Hirschhorn Joel N JN Hofman Albert A Holmen Jostein J Holmen Oddgeir Lingaas OL Hottenga Jouke-Jan JJ Howard Phil P Hsiung Chao A CA Hunt Steven C SC Ikram M Arfan MA Illig Thomas T Iribarren Carlos C Jensen Richard A RA Kähönen Mika M Kang Hyun H Kathiresan Sekar S Keating Brendan J BJ Khaw Kay-Tee KT Kim Yun Kyoung YK Kim Eric E Kivimaki Mika M Klopp Norman N Kolovou Genovefa G Komulainen Pirjo P Kooner Jaspal S JS Kosova Gulum G Krauss Ronald M RM Kuh Diana D Kutalik Zoltan Z Kuusisto Johanna J Kvaløy Kirsti K Lakka Timo A TA Lee Nanette R NR Lee I-Te IT Lee Wen-Jane WJ Levy Daniel D Li Xiaohui X Liang Kae-Woei KW Lin Honghuang H Lin Li L Lindström Jaana J Lobbens Stéphane S Männistö Satu S Müller Gabriele G Müller-Nurasyid Martina M Mach François F Markus Hugh S HS Marouli Eirini E McCarthy Mark I MI McKenzie Colin A CA Meneton Pierre P Menni Cristina C Metspalu Andres A Mijatovic Vladan V Moilanen Leena L Montasser May E ME Morris Andrew D AD Morrison Alanna C AC Mulas Antonella A Nagaraja Ramaiah R Narisu Narisu N Nikus Kjell K O'Donnell Christopher J CJ O'Reilly Paul F PF Ong Ken K KK Paccaud Fred F Palmer Cameron D CD Parsa Afshin A Pedersen Nancy L NL Penninx Brenda W BW Perola Markus M Peters Annette A Poulter Neil N Pramstaller Peter P PP Psaty Bruce M BM Quertermous Thomas T Rao Dabeeru C DC Rasheed Asif A Rayner N William N W R NWNWR Renström Frida F Rettig Rainer R Rice Kenneth M KM Roberts Robert R Rose Lynda M LM Rossouw Jacques J Samani Nilesh J NJ Sanna Serena S Saramies Jouko J Schunkert Heribert H Sebert Sylvain S Sheu Wayne H-H WH Shin Young-Ah YA Sim Xueling X Smit Johannes H JH Smith Albert V AV Sosa Maria X MX Spector Tim D TD Stančáková Alena A Stanton Alice A Stirrups Kathleen E KE Stringham Heather M HM Sundstrom Johan J Swift Amy J AJ Syvänen Ann-Christine AC Tai E-Shyong ES Tanaka Toshiko T Tarasov Kirill V KV Teumer Alexander A Thorsteinsdottir Unnur U Tobin Martin D MD Tremoli Elena E Uitterlinden Andre G AG Uusitupa Matti M Vaez Ahmad A Vaidya Dhananjay D van Duijn Cornelia M CM van Iperen Erik P A EPA Vasan Ramachandran S RS Verwoert Germaine C GC Virtamo Jarmo J Vitart Veronique V Voight Benjamin F BF Vollenweider Peter P Wagner Aline A Wain Louise V LV Wareham Nicholas J NJ Watkins Hugh H Weder Alan B AB Westra Harm-Jan HJ Wilks Rainford R Wilsgaard Tom T Wilson James F JF Wong Tien Y TY Yang Tsun-Po TP Yao Jie J Yengo Loic L Zhang Weihua W Zhao Jing Hua JH Zhu Xiaofeng X Bovet Pascal P Cooper Richard S RS Mohlke Karen L KL Saleheen Danish D Lee Jong-Young JY Elliott Paul P Gierman Hinco J HJ Willer Cristen J CJ Franke Lude L Hovingh G Kees GK Taylor Kent D KD Dedoussis George G Sever Peter P Wong Andrew A Lind Lars L Assimes Themistocles L TL Njølstad Inger I Schwarz Peter Eh PE Langenberg Claudia C Snieder Harold H Caulfield Mark J MJ Melander Olle O Laakso Markku M Saltevo Juha J Rauramaa Rainer R Tuomilehto Jaakko J Ingelsson Erik E Lehtimäki Terho T Hveem Kristian K Palmas Walter W März Winfried W Kumari Meena M Salomaa Veikko V Chen Yii-Der I YI Rotter Jerome I JI Froguel Philippe P Jarvelin Marjo-Riitta MR Lakatta Edward G EG Kuulasmaa Kari K Franks Paul W PW Hamsten Anders A Wichmann H-Erich HE Palmer Colin N A CNA Stefansson Kari K Ridker Paul M PM Loos Ruth J F RJF Chakravarti Aravinda A Deloukas Panos P Morris Andrew P AP Newton-Cheh Christopher C Munroe Patricia B PB
Nature genetics 20160912 10
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endotheli ...[more]