Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
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ABSTRACT:
SUBMITTER: Giri A
PROVIDER: S-EPMC6365102 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Giri Ayush A Hellwege Jacklyn N JN Keaton Jacob M JM Park Jihwan J Qiu Chengxiang C Warren Helen R HR Torstenson Eric S ES Kovesdy Csaba P CP Sun Yan V YV Wilson Otis D OD Robinson-Cohen Cassianne C Roumie Christianne L CL Chung Cecilia P CP Birdwell Kelly A KA Damrauer Scott M SM DuVall Scott L SL Klarin Derek D Cho Kelly K Wang Yu Y Evangelou Evangelos E Cabrera Claudia P CP Wain Louise V LV Shrestha Rojesh R Mautz Brian S BS Akwo Elvis A EA Sargurupremraj Muralidharan M Debette Stéphanie S Boehnke Michael M Scott Laura J LJ Luan Jian'an J Zhao Jing-Hua JH Willems Sara M SM Thériault Sébastien S Shah Nabi N Oldmeadow Christopher C Almgren Peter P Li-Gao Ruifang R Verweij Niek N Boutin Thibaud S TS Mangino Massimo M Ntalla Ioanna I Feofanova Elena E Surendran Praveen P Cook James P JP Karthikeyan Savita S Lahrouchi Najim N Liu Chunyu C Sepúlveda Nuno N Richardson Tom G TG Kraja Aldi A Amouyel Philippe P Farrall Martin M Poulter Neil R NR Laakso Markku M Zeggini Eleftheria E Sever Peter P Scott Robert A RA Langenberg Claudia C Wareham Nicholas J NJ Conen David D Palmer Colin Neil Alexander CNA Attia John J Chasman Daniel I DI Ridker Paul M PM Melander Olle O Mook-Kanamori Dennis Owen DO Harst Pim van der PV Cucca Francesco F Schlessinger David D Hayward Caroline C Spector Tim D TD Jarvelin Marjo-Riitta MR Hennig Branwen J BJ Timpson Nicholas J NJ Wei Wei-Qi WQ Smith Joshua C JC Xu Yaomin Y Matheny Michael E ME Siew Edward E EE Lindgren Cecilia C Herzig Karl-Heinz KH Dedoussis George G Denny Joshua C JC Psaty Bruce M BM Howson Joanna M M JMM Munroe Patricia B PB Newton-Cheh Christopher C Caulfield Mark J MJ Elliott Paul P Gaziano J Michael JM Concato John J Wilson Peter W F PWF Tsao Philip S PS Velez Edwards Digna R DR Susztak Katalin K O'Donnell Christopher J CJ Hung Adriana M AM Edwards Todd L TL
Nature genetics 20181221 1
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our t ...[more]
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