Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed M
PROVIDER: S-EPMC5043094 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Science translational medicine 20160301 331
Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of sIBM but all have failed. Because protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this feature of the disease. Using rat myoblast cultures, we found that up-regulation of the heat shock response with arimoclomol reduced key pathological markers of sIBM in vitro. Furthermore, i ...[more]