Analysis of morphine responses in mice reveals a QTL on Chromosome 7.
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ABSTRACT:
SUBMITTER: Crusio WE
PROVIDER: S-EPMC5043443 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Analysis of morphine responses in mice reveals a QTL on Chromosome 7.
Crusio Wim E WE Dhawan Esha E Chesler Elissa J EJ Delprato Anna A
F1000Research 20160902
In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are <i>Syt9</i> and <i>Ppfibp2</i>. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli. ...[more]
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