Ontology highlight
ABSTRACT:
SUBMITTER: Eby JM
PROVIDER: S-EPMC5044299 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Eby Jonathan M JM Kang Hee-Kap HK Tully Sean T ST Bindeman Wendy E WE Peiffer Daniel S DS Chatterjee Shilpak S Mehrotra Shikhar S Le Poole I Caroline IC
The Journal of investigative dermatology 20150109 6
In vitiligo, gradual cutaneous depigmentation and cytotoxic T-cell activity against melanocytes are accompanied by a paucity of regulatory T cells (Tregs) in vitiligo patient skin, indicating that autoimmune responses are not adequately held in check. Thus, we sought a means to repopulate patient skin with Tregs. We hypothesized that enhanced expression of CCL22 can promote Treg skin homing to suppress depigmentation. The mouse Ccl22 gene was cloned into an expression vector and resulting DNA wa ...[more]