Cannabisol, a novel ?9-THC dimer possessing a unique methylene bridge, isolated from Cannabis sativa.
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ABSTRACT:
SUBMITTER: Zulfiqar F
PROVIDER: S-EPMC5045039 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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Cannabisol, a novel Δ<sup>9</sup>-THC dimer possessing a unique methylene bridge, isolated from <i>Cannabis sativa</i>.
Zulfiqar Fazila F Ross Samir A SA Slade Desmond D Ahmed Safwat A SA Radwan Mohamed M MM Ali Zulfiqar Z Khan Ikhlas A IA ElSohly Mahmoud A MA
Tetrahedron letters 20120507 28
Cannabisol (<b>1</b>), a unique dimer of Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC) with a methylene bridge, was isolated from <i>Cannabis sativa</i>. This is the first example of a C-bridged dimeric cannabinoid. The structure of <b>1</b> was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of <b>1</b> is described. ...[more]
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