A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ⁹-tetrahydrocannabinol: Δ⁹-Tetrahydrocannabiphorol.

ABSTRACT: (-)-Trans-Δ⁹-tetrahydrocannabinol (Δ⁹-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ⁹-THC with a longer side chain have shown cannabimimetic properties far higher than Δ⁹-THC itself. In the attempt to define the phytocannabinoids profile that characterizes a medicinal cannabis variety, a new phytocannabinoid with the same structure of Δ⁹-THC but with a seven-term alkyl side chain was identified. The natural compound was isolated and fully characterized and its stereochemical configuration was assigned by match with the same compound obtained by a stereoselective synt

SUBMITTER: Citti C 

PROVIDER: S-EPMC6937300 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature