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Antileukemic ?-pyrone derivatives from the endophytic fungus Alternaria phragmospora.

ABSTRACT: Four new (1-4) and two known (5 and 6) ?-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3), 4-methoxy-6-methyl-5-(3-oxobutyl)-2H-pyran-2-one (4), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5), and 5-[(2E)-but-2-en-1-yl]-4-methoxy-6-methyl-2H-pyran-2-one (6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 ?M and against K562 cells with IC50 values of 4.5 and 1.5 ?M, respectively.

SUBMITTER: Metwaly AM

PROVIDER: S-EPMC5047437 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Antileukemic α-pyrone derivatives from the endophytic fungus Alternaria phragmospora.

Metwaly Ahmed M AM Fronczek Frank R FR Ma Guoyi G Kadry Hazem A HA El-Hela Atef A AA Mohammad Abd-Elsalam I AI Cutler Stephen J SJ Ross Samir A SA

Tetrahedron letters 20140601 24

Four new (1-4) and two known (5 and 6) α-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3), 4-methoxy-6-methyl-5-(3-oxobutyl)-2H ...[more]

PMID: 27708462

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