Ontology highlight
ABSTRACT:
SUBMITTER: Mattsson N
PROVIDER: S-EPMC5048367 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mattsson Niklas N Insel Philip S PS Palmqvist Sebastian S Portelius Erik E Zetterberg Henrik H Weiner Michael M Blennow Kaj K Hansson Oskar O
EMBO molecular medicine 20161004 10
Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors of AD diagnosis. Combinations improved the diagnostic accuracy (AUC 85.5% for T-tau, Ng, and NFL) co ...[more]