Ontology highlight
ABSTRACT:
SUBMITTER: Portelius E
PROVIDER: S-EPMC4643642 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Brain : a journal of neurology 20150915 Pt 11
Synaptic dysfunction is linked to cognitive symptoms in Alzheimer's disease. Thus, measurement of synapse proteins in cerebrospinal fluid may be useful biomarkers to monitor synaptic degeneration. Cerebrospinal fluid levels of the postsynaptic protein neurogranin are increased in Alzheimer's disease, including in the predementia stage of the disease. Here, we tested the performance of cerebrospinal fluid neurogranin to predict cognitive decline and brain injury in the Alzheimer's Disease Neuroim ...[more]