Ontology highlight
ABSTRACT:
SUBMITTER: Rossi SL
PROVIDER: S-EPMC5048596 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Rossi Sharyn L SL Lumpkin Casey J CJ Harris Ashlee W AW Holbrook Jennifer J Gentillon Cinsley C McCahan Suzanne M SM Wang Wenlan W Butchbach Matthew E R MER
Biochemical and biophysical research communications 20160915 2
Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits. To understand the molecular basis for the enhanced sensitivity of neurons to CPT, we examined the effects of compounds that inhibit TOP1-CPT, actinomycin D (ActD) and β-lapachone (β-Lap)-on primary cultured rat motor (MN) and cortical (CN) neurons as well as fibroblasts. Neuronal cel ...[more]