Ontology highlight
ABSTRACT:
SUBMITTER: Gokoolparsadh A
PROVIDER: S-EPMC5238604 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Gokoolparsadh Akira A Fang Zhiming Z Braidy Nady N Voineagu Irina I
Genomics data 20161223
Topoisomerase I is required for the proper expression of long genes (> 100 kb) in mouse and human cortical neurons, including many candidate genes for autism spectrum disorder (ASD) [1]. Given the important role of astrocytes in brain development [2], we investigated whether long genes, including autism susceptibility genes, also require topoisomerase I expression in human primary astrocytes. We carried genome-wide expression profiling of cultured human primary astrocytes following treatment wit ...[more]