Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification.

ABSTRACT:

Background

Converging evidence suggests that patients with first-episode psychosis who show a poor treatment response may have a higher degree of neurodevelopmental abnormalities than good Responders. Characterizing the disturbances in the relationship among brain regions (covariance) can provide more information on neurodevelopmental integrity than searching for localized changes in the brain. Graph-based connectomic approach can measure structural covariance thus providing information on the maturational processes. We quantified the structural covariance of cortical folding using graph theory in first-episode psychosis, to investigate if this systems-level approach would improve our understanding of the biological determinants of outcome in psychosis.

Methods

Magnetic Reso

SUBMITTER: Palaniyappan L 

PROVIDER: S-EPMC5049536 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature