Ontology highlight
ABSTRACT:
SUBMITTER: Earle SG
PROVIDER: S-EPMC5049680 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Earle Sarah G SG Wu Chieh-Hsi CH Charlesworth Jane J Stoesser Nicole N Gordon N Claire NC Walker Timothy M TM Spencer Chris C A CCA Iqbal Zamin Z Clifton David A DA Hopkins Katie L KL Woodford Neil N Smith E Grace EG Ismail Nazir N Llewelyn Martin J MJ Peto Tim E TE Crook Derrick W DW McVean Gil G Walker A Sarah AS Wilson Daniel J DJ
Nature microbiology 20160404
Bacteria pose unique challenges for genome-wide association studies because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome(1,2). Although methods developed for human studies can correct for strain structure(3,4), this risks considerable loss-of-power because genetic differences between strains often contribute substantial phenotypic variability(5). Here, we propose a new method that captures lineage-level associations even when locus-specific ...[more]