Ontology highlight
ABSTRACT:
SUBMITTER: Qian SW
PROVIDER: S-EPMC5049932 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Qian Shu-Wen SW Liu Yan Y Wang Jue J Nie Ji-Chan JC Wu Meng-Yuan MY Tang Yan Y Zhao Ya-Xin YX Li Xi X Huang Hai-Yan HY Guo Liang L Liu Xi-Shi XS Xu Cong-Jian CJ Tang Qi-Qun QQ
EBioMedicine 20160730
Similar to estrogens, bone morphogenetic protein 4 (BMP4) promotes the accumulation of more metabolically active subcutaneous fat and reduction of visceral fat. However, whether there is a cross-talk between BMP4 and estrogen signaling remained unknown. Herein, we found that BMP4 deficiency in white adipose tissue (WAT) increased the estrogen receptor α (ERα) level and its signaling, which prevented adult female mice from developing high fat diet (HFD)-induced obesity and insulin resistance; est ...[more]