Ontology highlight
ABSTRACT:
SUBMITTER: Chang AL
PROVIDER: S-EPMC5050119 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chang Alan L AL Miska Jason J Wainwright Derek A DA Dey Mahua M Rivetta Claudia V CV Yu Dou D Kanojia Deepak D Pituch Katarzyna C KC Qiao Jian J Pytel Peter P Han Yu Y Wu Meijing M Zhang Lingjiao L Horbinski Craig M CM Ahmed Atique U AU Lesniak Maciej S MS
Cancer research 20160816 19
In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC). However, the mechanistic details of how Tregs and MDSCs are recruited in various tumors are not yet well understood. Here we report that macrophages and microglia within the glioma microenvironment produce CCL2, a chemokine that is critical for recruiting both CCR4<sup>+</sup> Treg and C ...[more]