Unknown

Dataset Information

0

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer.


ABSTRACT: Early detection and efficient treatment modality of early-stage peripheral lung cancer is essential. Current nonsurgical treatments for peripheral lung cancer show critical limitations associated with various complications, requiring alternative minimally invasive therapeutics. Porphysome nanoparticle-enabled fluorescence-guided transbronchial photothermal therapy (PTT) of peripheral lung cancer was developed and demonstrated in preclinical animal models. Systemically administered porphysomes accumulated in lung tumors with significantly enhanced disease-to-normal tissue contrast, as confirmed in three subtypes of orthotopic human lung cancer xenografts (A549, H460, and H520) in mice and in an orthotopic VX2 tumor in rabbits. An in-house prototype fluorescence bronchoscope demonstrated the capability of porphysomes for in vivo imaging of lung tumors in the mucosal/submucosal layers, providing real-time fluorescence guidance for transbronchial PTT. Porphysomes also enhanced the efficacy of transbronchial PTT significantly and resulted in selective and efficient tumor tissue ablation in the rabbit model. A clinically used cylindrical diffuser fiber successfully achieved tumor-specific thermal ablation, showing promising evidence for the clinical translation of this novel platform to impact upon nonsurgical treatment of early-stage peripheral lung cancer. Cancer Res; 76(19); 5870-80. ©2016 AACR.

SUBMITTER: Jin CS 

PROVIDER: S-EPMC5050138 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer.

Jin Cheng S CS   Wada Hironobu H   Anayama Takashi T   McVeigh Patrick Z PZ   Hu Hsin Pei HP   Hirohashi Kentaro K   Nakajima Takahiro T   Kato Tatsuya T   Keshavjee Shaf S   Hwang David D   Wilson Brian C BC   Zheng Gang G   Yasufuku Kazuhiro K  

Cancer research 20160819 19


Early detection and efficient treatment modality of early-stage peripheral lung cancer is essential. Current nonsurgical treatments for peripheral lung cancer show critical limitations associated with various complications, requiring alternative minimally invasive therapeutics. Porphysome nanoparticle-enabled fluorescence-guided transbronchial photothermal therapy (PTT) of peripheral lung cancer was developed and demonstrated in preclinical animal models. Systemically administered porphysomes ac  ...[more]

Similar Datasets

| S-EPMC10064382 | biostudies-literature
| S-EPMC9469762 | biostudies-literature
| S-EPMC7388566 | biostudies-literature
| S-EPMC7440722 | biostudies-literature
| S-EPMC10984635 | biostudies-literature
| S-EPMC7165338 | biostudies-literature
2022-01-20 | GSE167944 | GEO
| S-EPMC6790847 | biostudies-literature
| S-EPMC4305276 | biostudies-literature
| S-EPMC8089124 | biostudies-literature