Ontology highlight
ABSTRACT:
SUBMITTER: Chin CJ
PROVIDER: S-EPMC5052131 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chin Chee Jia CJ Cooper Aaron R AR Lill Georgia R GR Evseenko Denis D Zhu Yuhua Y He Chong Bin CB Casero David D Pellegrini Matteo M Kohn Donald B DB Crooks Gay M GM
Stem cells (Dayton, Ohio) 20160328 5
Although clonal studies of lineage potential have been extensively applied to organ specific stem and progenitor cells, much less is known about the clonal origins of lineages formed from the germ layers in early embryogenesis. We applied lentiviral tagging followed by vector integration site analysis (VISA) with high-throughput sequencing to investigate the ontogeny of the hematopoietic, endothelial and mesenchymal lineages as they emerge from human embryonic mesoderm. In contrast to studies th ...[more]