Ontology highlight
ABSTRACT:
SUBMITTER: Kishikawa T
PROVIDER: S-EPMC5052683 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160926
Highly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles of the satellite RNAs in carcinogenesis, we construct mouse PanIN-derived cells expressing major satellite (MajSAT) RNA and show increased malignant prop ...[more]