Ontology highlight
ABSTRACT:
SUBMITTER: Humpton TJ
PROVIDER: S-EPMC6726540 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Humpton Timothy J TJ Alagesan Brinda B DeNicola Gina M GM Lu Dan D Yordanov Georgi N GN Leonhardt Carl S CS Yao Melissa A MA Alagesan Priya P Zaatari Maya N MN Park Youngkyu Y Skepper Jeremy N JN Macleod Kay F KF Perez-Mancera Pedro A PA Murphy Michael P MP Evan Gerard I GI Vousden Karen H KH Tuveson David A DA
Cancer discovery 20190701 9
Activating <i>KRAS</i> mutations are found in nearly all cases of pancreatic ductal adenocarcinoma (PDAC), yet effective clinical targeting of oncogenic KRAS remains elusive. Understanding of KRAS-dependent PDAC-promoting pathways could lead to the identification of vulnerabilities and the development of new treatments. We show that oncogenic <i>KRAS</i> induces <i>BNIP3L</i>/NIX expression and a selective mitophagy program that restricts glucose flux to the mitochondria and enhances redox capac ...[more]