Ontology highlight
ABSTRACT:
SUBMITTER: Dover K
PROVIDER: S-EPMC5052690 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Dover Katarzyna K Marra Christopher C Solinas Sergio S Popovic Marko M Subramaniyam Sathyaa S Zecevic Dejan D D'Angelo Egidio E Goldfarb Mitchell M
Nature communications 20160926
Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Na<sub>v</sub>)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Na<sub>v</sub> inactivation, dis ...[more]