Ontology highlight
ABSTRACT:
SUBMITTER: Arakawa Y
PROVIDER: S-EPMC2172896 | biostudies-other | 2003 Apr
REPOSITORIES: biostudies-other
Arakawa Yoshiki Y Bito Haruhiko H Furuyashiki Tomoyuki T Tsuji Takahiro T Takemoto-Kimura Sayaka S Kimura Kazuhiro K Nozaki Kazuhiko K Hashimoto Nobuo N Narumiya Shuh S
The Journal of cell biology 20030421 2
Rho-GTPase has been implicated in axon outgrowth. However, not all of the critical steps controlled by Rho have been well characterized. Using cultured cerebellar granule neurons, we show here that stromal cell-derived factor (SDF)-1alpha, a neural chemokine, is a physiological ligand that can turn on two distinct Rho-dependent pathways with opposite consequences. A low concentration of the ligand stimulated a Rho-dependent pathway that mediated facilitation of axon elongation. In contrast, Rho/ ...[more]