Ontology highlight
ABSTRACT:
SUBMITTER: Lee KT
PROVIDER: S-EPMC5052723 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160928
Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis; however, treatment options remain limited. Here we report the construction of 264 signature-tagged gene-deletion strains for 129 putative kinases, and examine their phenotypic traits under 30 distinct in vitro growth conditions and in two different hosts (insect larvae and mice). Clustering analysis of in vitro phenotypic traits indicates that several of these kinases have roles in known signalling pathways, and ...[more]