Ontology highlight
ABSTRACT:
SUBMITTER: Renner K
PROVIDER: S-EPMC5053150 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Renner Kerstin K Hellerbrand Sonja S Hermann Fabian F Riedhammer Christine C Talke Yvonne Y Schiechl Gabriela G Rodriguez Gomez Manuel M Kutzi Simone S Halbritter Dagmar D Goebel Nicole N Brühl Hilke H Weissert Robert R Mack Matthias M
JCI insight 20161006 16
Little is known about the role of IL-3 in multiple sclerosis (MS) in humans and in experimental autoimmune encephalomyelitis (EAE). Using myelin oligodendrocyte glycoprotein (MOG) peptide-induced EAE, we show that CD4<sup>+</sup> T cells are the main source of IL-3 and that cerebral IL-3 expression correlates with the influx of T cells into the brain. Blockade of IL-3 with monoclonal antibodies, analysis of IL-3 deficient mice, and adoptive transfer of leukocytes demonstrate that IL-3 plays an i ...[more]