Ontology highlight
ABSTRACT:
SUBMITTER: Demeulemeester J
PROVIDER: S-EPMC5053271 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Demeulemeester Jonas J De Rijck Jan J Gijsbers Rik R Debyser Zeger Z
BioEssays : news and reviews in molecular, cellular and developmental biology 20150821 11
Here, we review genomic target site selection during retroviral integration as a multistep process in which specific biases are introduced at each level. The first asymmetries are introduced when the virus takes a specific route into the nucleus. Next, by co-opting distinct host cofactors, the integration machinery is guided to particular chromatin contexts. As the viral integrase captures a local target nucleosome, specific contacts introduce fine-grained biases in the integration site distribu ...[more]