Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell RS
PROVIDER: S-EPMC509299 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Mitchell Rick S RS Beitzel Brett F BF Schroder Astrid R W AR Shinn Paul P Chen Huaming H Berry Charles C CC Ecker Joseph R JR Bushman Frederic D FD
PLoS biology 20040817 8
The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV), avian sarcoma-leukosis virus (ASLV), and murine leukemia virus (MLV). Effects of gene activity on integration targeting were assessed by transcriptional profiling of infected cells. Integration by HIV vectors, analyzed in two ...[more]