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Soluble Levels of Receptor for Advanced Glycation Endproducts (RAGE) and Progression of Atherosclerosis in Individuals Infected with Human Immunodeficiency Virus: ACTG NWCS 332.

ABSTRACT: Identification of biomarkers and/or mediators of cardiovascular disease (CVD) associated with HIV infection would be of diagnostic and therapeutic value. As soluble receptor for advanced glycation endproducts (sRAGE) and endogenous secretory (esRAGE) have been implicated in vascular complications in other settings, we investigated whether either soluble form of RAGE was associated with changes in carotid intima-media thickness (CIMT) in HIV-infected patients and HIV-uninfected controls. We found no differences in sRAGE, esRAGE, or CIMT among groups at study entry, or in yearly rates of change in sRAGE, esRAGE, or CIMT by HIV-serostatus (all p?>?0.10). However, yearly rates of change in sRAGE (p?=?0.07) and esRAGE (p?

SUBMITTER: Danoff A

PROVIDER: S-EPMC5053332 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Soluble Levels of Receptor for Advanced Glycation Endproducts (RAGE) and Progression of Atherosclerosis in Individuals Infected with Human Immunodeficiency Virus: ACTG NWCS 332.

Danoff Ann A Kendall Michelle A MA Currier Judith S JS Kelesidis Theodoros T Schmidt Ann Marie AM Aberg Judith A JA

Inflammation 20160801 4

Identification of biomarkers and/or mediators of cardiovascular disease (CVD) associated with HIV infection would be of diagnostic and therapeutic value. As soluble receptor for advanced glycation endproducts (sRAGE) and endogenous secretory (esRAGE) have been implicated in vascular complications in other settings, we investigated whether either soluble form of RAGE was associated with changes in carotid intima-media thickness (CIMT) in HIV-infected patients and HIV-uninfected controls. We found ...[more]

PMID: 27216802

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Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.

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