Ontology highlight
ABSTRACT:
SUBMITTER: Panchanathan R
PROVIDER: S-EPMC5053719 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Panchanathan Ravichandran R Liu Hongzhu H Choubey Divaker D
Oncotarget 20160501 19
The molecular mechanisms by which hypoxia contributes to prostatic chronic inflammation (PCI) remain largely unknown. Because hypoxia stimulates the transcriptional activity of NF-κB, which "primes" cells for inflammasome activation by inducing the expression of NLRP3 or AIM2 receptor and pro-IL-1β, we investigated whether hypoxia could activate the NLRP3 and AIM2 inflammasome in human normal prostate epithelial cells (PrECs) and cancer cell lines. Here we report that hypoxia (1% O2) treatment o ...[more]