Ontology highlight
ABSTRACT:
SUBMITTER: Gillespie JR
PROVIDER: S-EPMC5053811 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Gillespie J R JR Bush J R JR Bell G I GI Aubrey L A LA Dupuis H H Ferron M M Kream B B DiMattia G G Patel S S Woodgett J R JR Karsenty G G Hess D A DA Beier F F
Endocrinology 20130731 10
Glycogen synthase kinase 3 β (GSK-3β) is an essential negative regulator or "brake" on many anabolic-signaling pathways including Wnt and insulin. Global deletion of GSK-3β results in perinatal lethality and various skeletal defects. The goal of our research was to determine GSK-3β cell-autonomous effects and postnatal roles in the skeleton. We used the 3.6-kb Col1a1 promoter to inactivate the Gsk3b gene (Col1a1-Gsk3b knockout) in skeletal cells. Mutant mice exhibit decreased body fat and postna ...[more]