Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC6684275 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Sharma Arpit A Oonthonpan Lalita L Sheldon Ryan D RD Rauckhorst Adam J AJ Zhu Zhiyong Z Tompkins Sean C SC Cho Kevin K Grzesik Wojciech J WJ Gray Lawrence R LR Scerbo Diego A DA Pewa Alvin D AD Cushing Emily M EM Dyle Michael C MC Cox James E JE Adams Chris C Davies Brandon S BS Shields Richard K RK Norris Andrew W AW Patti Gary G Zingman Leonid V LV Taylor Eric B EB
eLife 20190718
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Carrier (MPC) deletion in mice diverted pyruvate into circulating lactate. This switch disinhibited muscle fatty acid oxidation and drove Cori Cycling that contributed to increased energy expenditure. Loss of muscle MPC activity led to strikingly decrea ...[more]