Ontology highlight
ABSTRACT:
SUBMITTER: Losada A
PROVIDER: S-EPMC5054363 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Losada Alejandro A Muñoz-Alonso María José MJ García Carolina C Sánchez-Murcia Pedro A PA Martínez-Leal Juan Fernando JF Domínguez Juan Manuel JM Lillo M Pilar MP Gago Federico F Galmarini Carlos M CM
Scientific reports 20161007
eEF1A2 is one of the isoforms of the alpha subunit of the eukaryotic Elongation Factor 1. It is overexpressed in human tumors and is endowed with oncogenic properties, favoring tumor cell proliferation while inhibiting apoptosis. We demonstrate that plitidepsin, an antitumor agent of marine origin that has successfully completed a phase-III clinical trial for multiple myeloma, exerts its antitumor activity by targeting eEF1A2. The drug interacts with eEF1A2 with a K<sub>D</sub> of 80 nM and a ta ...[more]