Ontology highlight
ABSTRACT:
SUBMITTER: Crepin T
PROVIDER: S-EPMC4227793 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Crepin Thibaut T Shalak Vyacheslav F VF Yaremchuk Anna D AD Vlasenko Dmytro O DO McCarthy Andrew A Negrutskii Boris S BS Tukalo Michail A MA El'skaya Anna V AV
Nucleic acids research 20141017 20
Eukaryotic elongation factor eEF1A transits between the GTP- and GDP-bound conformations during the ribosomal polypeptide chain elongation. eEF1A*GTP establishes a complex with the aminoacyl-tRNA in the A site of the 80S ribosome. Correct codon-anticodon recognition triggers GTP hydrolysis, with subsequent dissociation of eEF1A*GDP from the ribosome. The structures of both the 'GTP'- and 'GDP'-bound conformations of eEF1A are unknown. Thus, the eEF1A-related ribosomal mechanisms were anticipated ...[more]