Ontology highlight
ABSTRACT:
SUBMITTER: Van Allen EM
PROVIDER: S-EPMC5054517 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Van Allen Eliezer M EM Miao Diana D Schilling Bastian B Shukla Sachet A SA Blank Christian C Zimmer Lisa L Sucker Antje A Hillen Uwe U Foppen Marnix H Geukes MHG Goldinger Simone M SM Utikal Jochen J Hassel Jessica C JC Weide Benjamin B Kaehler Katharina C KC Loquai Carmen C Mohr Peter P Gutzmer Ralf R Dummer Reinhard R Gabriel Stacey S Wu Catherine J CJ Schadendorf Dirk D Garraway Levi A LA
Science (New York, N.Y.) 20150910 6257
Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic melanoma by inhibiting immune checkpoint activity, but clinical predictors of response to these therapies remain incompletely characterized. To investigate the roles of tumor-specific neoantigens and alterations in the tumor microenvironment in the response to ipilimumab, we analyzed whole exomes from pretreatment melano ...[more]