Ontology highlight
ABSTRACT:
SUBMITTER: Keenan TE
PROVIDER: S-EPMC6599710 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Keenan Tanya E TE Burke Kelly P KP Van Allen Eliezer M EM
Nature medicine 20190306 3
Despite impressive durable responses, immune checkpoint inhibitors do not provide a long-term benefit to the majority of patients with cancer. Understanding genomic correlates of response and resistance to checkpoint blockade may enhance benefits for patients with cancer by elucidating biomarkers for patient stratification and resistance mechanisms for therapeutic targeting. Here we review emerging genomic markers of checkpoint blockade response, including those related to neoantigens, antigen p ...[more]