Unknown

Dataset Information

0

Nutrient reduction induced stringent responses promote bacterial quorum-sensing divergence for population fitness.


ABSTRACT: Bacteria use a cell-cell communication system termed quorum-sensing (QS) to adjust population size by coordinating the costly but beneficial cooperative behaviors. It has long been suggested that bacterial social conflict for expensive extracellular products may drive QS divergence and cause the "tragedy of the commons". However, the underlying molecular mechanism of social divergence and its evolutionary consequences for the bacterial ecology still remain largely unknown. By using the model bacterium Pseudomonas aeruginosa PAO1, here we show that nutrient reduction can promote QS divergence for population fitness during evolution but requiring adequate cell density. Mechanically, decreased nutrient supplies can induce RpoS-directed stringent response and enhance the selection pressure on lasR gene, and lasR mutants are evolved in association with the DNA mismatch repair "switch-off". The lasR mutants have higher relative fitness than QS-intact individuals due to their energy-saving characteristic under nutrient decreased condition. Furthermore an optimal incorporation of lasR mutants is capable of maximizing the fitness of entire population during in vitro culture and the colonization in mouse lung. Consequently, rather than worsen the population health, QS-coordinated social divergence is an elaborate evolutionary strategy that renders the entire bacterial population more fit in tough times.

SUBMITTER: Zhao K 

PROVIDER: S-EPMC5054682 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Nutrient reduction induced stringent responses promote bacterial quorum-sensing divergence for population fitness.

Zhao Kelei K   Zhou Xikun X   Li Wujiao W   Zhang Xiuyue X   Yue Bisong B  

Scientific reports 20161007


Bacteria use a cell-cell communication system termed quorum-sensing (QS) to adjust population size by coordinating the costly but beneficial cooperative behaviors. It has long been suggested that bacterial social conflict for expensive extracellular products may drive QS divergence and cause the "tragedy of the commons". However, the underlying molecular mechanism of social divergence and its evolutionary consequences for the bacterial ecology still remain largely unknown. By using the model bac  ...[more]

Similar Datasets

| S-EPMC3361460 | biostudies-literature
| S-EPMC298792 | biostudies-literature
| S-EPMC4718088 | biostudies-literature
| S-EPMC5018880 | biostudies-other
| S-EPMC4577073 | biostudies-literature
| S-EPMC8492804 | biostudies-literature
| S-EPMC7334417 | biostudies-literature
| S-EPMC3158151 | biostudies-literature
| S-EPMC2223271 | biostudies-literature
| S-EPMC6373464 | biostudies-literature