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Promise of cancer stem cell vaccine.


ABSTRACT: Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy.

SUBMITTER: Zhou L 

PROVIDER: S-EPMC5054775 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Promise of cancer stem cell vaccine.

Zhou Li L   Lu Lin L   Wicha Max S MS   Chang Alfred E AE   Xia Jian-chuan JC   Ren Xiubao X   Li Qiao Q  

Human vaccines & immunotherapeutics 20150101 12


Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy. ...[more]

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