Ontology highlight
ABSTRACT:
SUBMITTER: Andersen R
PROVIDER: S-EPMC5054777 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Andersen Rikke R Donia Marco M Westergaard Marie Christine Wulff MC Pedersen Magnus M Hansen Morten M Svane Inge Marie IM
Human vaccines & immunotherapeutics 20150101 12
Personalized cancer immunotherapy based on infusion of T cells holds the promise to specifically target a patient's individual tumor. Accumulating evidence indicates that the T cells mediating these tumor regressions after cancer immunotherapies may primarily target patient-specific mutations expressed by the patients' tumors and that the presence of these "neo-antigen" specific T-cells may be related to a high number of mutations in the tumor. In melanoma, treatment with autologous tumor-infilt ...[more]